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Clinical Study

Radiotherapy for Gum Hypertrophy in Acute Myeloid Leukemia

Authors: Daniel E Roos* and Hui Chin Tee

Publication Date: 01 October, 2025

DOI: https://doi.org/10.51219/MCCRJ/Daniel-E-Roos/401

Citation: Roos DE, Tee HC. Radiotherapy for Gum Hypertrophy in Acute Myeloid Leukemia. Medi Clin Case Rep J 2025;3(4):1425-1426.

Copyright:© 2025 Roos DE, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which

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Abstract
A 67-year-old man with acute myeloid leukemia (AML) was referred for palliative radiotherapy. He had a history of aplastic anemia diagnosed in 2020, requiring a matched sibling donor allogeneic stem cell transplant in 2023. He subsequently developed myelodysplastic syndrome, progressing in 2024 to AML which proved refractory to chemotherapy. This led to gradually worsening gum hypertrophy encasing most of his teeth (Panel A), severely limiting oral intake and impairing speech. He was offered a short course of low dose radiotherapy to the gingiva (20 Gray in 10 treatments, 2.0 Gray/day over 2 weeks). The hypertrophic tissue regressed rapidly, with a near complete symptomatic response by one month following resolution of the acute mucositis (Panel B). He was able to eat a steak for the first time in 6 months. Gum hypertrophy in AML is due to leukemic infiltration of the gingival tissues. When chemo-refractory, radiotherapy is an effective treatment option.

Keywords: Acute Myeloid Leukemia; Gum Hypertrophy; Palliation; Radiotherapy 


Panel A


Panel B