Editorial Board Member

Biography

Dr Khageswar Sahu has made outstanding contributions in development of antimicrobial photodynamic therapy (aPDT) technology for inactivation of antibiotic-resistant bacteria at RRCAT and its clinical translation. The extensive studies carried out by Dr Sahu in chronic wound models of diabetic mice demonstrated that it is possible to arrive at an aPDT window that results not only in rapid killing of bacteria, but also faster wound closure. The study was published in Laser Therapy and awarded Prof Mien KAO by the editorial board of Laser Therapy journal. One remarkable achievement of him is development of a photosensitizer formulation comprising an inorganic salt that amplifies aPDT efficacy. He has also developed various photoactivable drug conjugates, polymeric films which demonstrate controlled delivery of drugs for wound healing applications. The in-depth preclinical investigations carried out by him paved the way for development of four handheld, LED based, first of a kind in India, point of care (POCs) devices. Dr Sahu has contributed immensely to the clinical studies utilizing these POCs and the optimized a photosensitizer formulation for treatment of infections of external ear, nasal cavity and diabetic foot ulcers. These comprehensive research investigations have culminated into two products; NasolightTM and EarolightTM. One of his noteworthy contributions is development of a novel theranostic concept based on the prodrug; delta amino levulinic acid for fluorescence imaging based detection of infection and assessment of aPDT for bacteria infected wounds of mice. Another remarkable contribution made by him is on demonstration of the benefit conferred by low level laser therapy (LLLT), as an adjunct to conventional treatment, for the healing and wound repair of recalcitrant diabetic foot ulcers.Recently, he has studied effect of Photobiomodulation on stem cells which has immense potential for cell therapy and regenerative medicine. His research contributions published in peer reviewed journals have received good citations and have earned him recognition in academic community of India as a leading scientist in the field of aPDT.